VITAS, a sensitive<i>in vivo</i>selection assay to discover enzymes producing antiviral natural products

Alharbi AF, Kim H, Chumroo D, Ji Y, Hakil M, Ebrahimi KH

selection assay named Viral polymerase-Inhibition Toxin-Associated Selection (VITAS). We show that the assay works with enzymes from three Kingdoms of life.

Keywords:

Chemistry

,

Enzyme

,

In vivo

,

Toxin

,

Genetics

,

Selection (genetic algorithm)

,

Biology

,

Virology

,

Computational biology

,

Biochemistry